Name: BCAS2抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： BCAS2抗原（重組蛋白）

英文名稱： BCAS2 Antigen (Recombinant Protein)

別名： DAM1; SPF27; Snt309

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Full length fusion protein

技術規格

Full name:	breast carcinoma amplified sequence 2
Synonyms:	DAM1; SPF27; Snt309
Swissprot:	O75934
Gene Accession:	BC005285
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with TR∫ (thyroid hormone receptor beta), ER? (estrogen receptor alpha), ER∫, PR (progesterone receptor), and PPAR? (Peroxisome proliferator-activated receptor gamma). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer.

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