Name: ATXN3抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： ATXN3抗原（重組蛋白）

英文名稱： ATXN3 Antigen (Recombinant Protein)

別名： ataxin 3; AT3; JOS; MJD; ATX3; MJD1; SCA3

相關(guān)類別：抗原

儲(chǔ) 存： 冷凍（-20℃）

概述

Fusion protein corresponding to a region derived from 112-361 amino acids of human ATXN3

技術(shù)規(guī)格

Full name:	ataxin 3
Synonyms:	AT3; JOS; MJD; ATX3; MJD1; SCA3
Swissprot:	P54252
Gene Accession:	BC033711
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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