Name: DNASE1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： DNASE1抗原（重組蛋白）

英文名稱： DNASE1 Antigen (Recombinant Protein)

別名： DNL1; DRNI

儲存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to C terminal 260 amino acids of human DNASE1

技術規格：

Full name:	deoxyribonuclease I
Synonyms:	DNL1; DRNI
Swissprot:	P24855
Gene Accession:	BC029437
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE11 through DNASE16, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

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