Name: DOK4抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：DOK4抗原（重組蛋白）

英文名稱： DOK4 Antigen (Recombinant Protein)

儲存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to a region derived from 7-237 amino acids of human DOK4

技術規(guī)格：

Full name:	docking protein 4
Swissprot:	Q8TEW6
Gene Accession:	BC001540
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Docking protein 4 is a protein that in humans is encoded by the DOK4 gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.

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