Name: USP2抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：USP2抗原（重組蛋白）

英文名稱： USP2 Antigen (Recombinant Protein)

別名： USP9; UBP41

儲存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to a region derived from C terminal 250 amino acids of human USP2

技術規格：

Full name:	ubiquitin specific peptidase 2
Synonyms:	USP9; UBP41
Swissprot:	O75604
Gene Accession:	BC002854
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

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