Name: TPMT 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：TPMT 抗原（重組蛋白）

英文名稱： TPMT Antigen (Recombinant Protein)

別名： thiopurine S-methyltransferase; TPMTD

儲存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to a region derived from 1-245 amino acids of human TPMT

技術規格：

Full name:	thiopurine S-methyltransferase
Synonyms:	TPMTD
Swissprot:	P51580
Gene Accession:	BC005339
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

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