Name: EIF3C 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：EIF3C 抗原（重組蛋白）

英文名稱： EIF3C Antigen (Recombinant Protein)

別名： eukaryotic translation initiation factor 3 subunit C; EIF3CL; EIF3S8; eIF3-p110

儲存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to a region derived from 714-913 amino acids of human EIF3C

技術(shù)規(guī)格：

Full name:	eukaryotic translation initiation factor 3 subunit C
Synonyms:	EIF3CL; EIF3S8; eIF3-p110
Swissprot:	Q99613
Gene Accession:	BC001571
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

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