Name: DLAT 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：DLAT 抗原（重組蛋白）

英文名稱：DLAT Antigen (Recombinant Protein)

別名： dihydrolipoamide S-acetyltransferase; DLTA; PDCE2; PDC-E2

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to C terminal 200 amino acids of human DLAT

技術規格

Full name:	dihydrolipoamide S-acetyltransferase
Synonyms:	DLTA; PDCE2; PDC-E2
Swissprot:	P10515
Gene Accession:	BC039084
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

展開全部

男人的天堂新地址免费_1级a性国产乱子伦_久久久精品成人欧美大片_av在线资源人妻无码_日本色意久久久_亚洲喷水字幕无码少妇一区永久_精品国产成人A区在线观看= _婷婷五月av综合_天天爽天天舔天天干_中文字幕欧美激情

ELISA試劑盒