購物車
幫助
021-54845833/15800441009
反應種屬： Human
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Background: |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. |
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Applications: |
WB, IHC |
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Name of antibody: |
PSMA7 |
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Immunogen: |
Fusion protein of human PSMA7 |
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Full name: |
proteasome subunit alpha 7 |
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Synonyms: |
C6; HSPC; RC6-1; XAPC7; HEL-S-276 |
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SwissProt: |
O14818 |
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IHC positive control: |
Human pancreas tissue and Human breast tissue; Human thyroid tissue |
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IHC Recommend dilution: |
500-2000 |
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WB Predicted band size: |
28 KD |
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WB Positive control: |
A549, MCF7, 293T, Hela, A431, Raji, HepG2, K562, COLO205 cell lysates |
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WB Recommended dilution: |
500-2000 |
